Hokie Football 2010
| Opponent | Date | Time |
| Boise State | Monday, September 6 | 8:00pm |
| James Madison | Saturday, September 11 | TBA |
| East Carolina | Saturday, September 18 | TBA |
| Boston College | Saturday, September 25 | TBA |
| NC State | Saturday, October 2 | TBA |
| Central Michigan | Saturday, October 9 | TBA |
| Wake Forest | Saturday, October 16 | TBA |
| Duke | Saturday, October 23 | TBA |
| Georgia Tech | Thursday, November 4 | 7:30pm |
| North Carolina | Saturday, November 13 | TBA |
| Miami | Saturday, November 20 | TBA |
| Virginia | Saturday, November 27 | TBA |